People often throw out claims like 'nothing matters anyway' and 'who cares in the grand scheme of things'. Sometimes when justifying not doing anything with their life. I don't think it's a valid argument. Many religious people claim certainty about every action having cosmic significance. The answer is in between: The existence of cosmic meaning is uncertain due to [[All human knowledge is fallible|fallibilism]], which means no one can claim either a 0% or 100% chance of cosmic meaning. If the probability isn't zero, then the [[Expected value|expected significance]] of trying to do good isn't zero either. Even a tiny chance still produces a positive expected significance. Within that uncertainty, the actions we take carry cosmic significance in a practical sense. For example take a supernatural system where human lives are cosmically meaningful, and imagine some world where there is a 1% chance that this system exists. In that world, if you save 100 lives, that is equivalent to saving 1 life in a cosmically meaningful act. The uncertainty gives your actions expected cosmic meaning. No matter how small the odds are, because they are not zero, there is a cosmically significant expected value. The next question then is about [[What is good|what is good]], and how we can do the most good. Some may think the chance of anything mattering in a cosmically significant way is so low that they still choose to live as if nothing really matters. But if nothing really matters, whatever you do with your life makes no difference, so you may as well try to do good.